翻訳と辞書 Words near each other ・ Methylumbelliferyl-acetate deacetylase ・ Methylvanillylecgonine ・ Methyphobia ・ Methyprylon ・ Methysergide ・ Methysia ・ Methysia melanota ・ Methysia notabilis ・ Methysticin ・ Methylestrenolone ・ Methylethyl ketone oxime ・ Methylethyltryptamine ・ Methylfentanyl ・ Methylfuran ・ Methylglucoside ・ Methylglutaconyl-CoA hydratase ・ Methylglutamate dehydrogenase ・ Methylglyoxal ・ Methylglyoxal pathway ・ Methylglyoxal reductase (NADH-dependent) ・ Methylglyoxal reductase (NADPH-dependent) ・ Methylglyoxal synthase ・ Methylguanidinase ・ Methylheptane ・ Methylhexanamine ・ Methylhexane ・ Methylhistamine ・ Methylhomatropine ・ Methylhydrazines ・ Methylibium petroleiphilum Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Methylglutaconyl-CoA hydratase ： ウィキペディア英語版 Methylglutaconyl-CoA hydratase 3-methylglutaconyl-CoA hydratase (also known as AUH) is an enzyme encoded by the ''AUH'' gene on chromosome 19. It is a member of the enoyl-CoA hydratase/isomerase superfamily, but it is the only member of that family that is able to bind to RNA. Not only does it bind to RNA, AUH has also been observed to be involved in the metabolic enzymatic activity, making it a dual-role protein. Mutations of this gene have been found to cause a disease called 3-Methylglutaconic Acuduria Type 1. == Structure == The enzyme AUH has a molecular mass of 32 kDa and the AUH gene consists of 18 exons, is 1.7 kb long, and is mainly found in kidney, skeletal muscle, heart, liver, and spleen cells. AUH has a similar fold that is found in other members of the enoyl-CoA hydratase/isomerase family; however, it is a hexamer as a dimer of trimers. Also unlike other members of its family, AUH’s surface is positively charged in contrast to the negative charge seen on that of other classes. Between the two trimers of the enzyme, wide clefts were seen with a highly positive charge and lysine residues in alpha helix H1. These lysine residues were shown to be the main reason why AUH is able to bind to RNA rather than its counterparts. Moreover, it has been found that the oligomeric state of AUH depends on whether or not RNA is present. If RNA is near, the AUH will take on an asymmetric shape that loses the 3- and 2-fold crystallographic rotation axes, because of realignment of the internal 3-fold axes of the trimers. Because this enzyme has weak, short-chain enoyl-CoA hydratase activity, AUH also has a hydrase active-site pocket created by H2A-H3 alpha-helices and the H4A 310 helix of one subunit, and the H8 and H9 alpha-helices of the adjacent subunit within the same trimer. This active-site pocket is not affected by the change in oligomeric state when AUH is in the presence of RNA. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Methylglutaconyl-CoA hydratase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.